Author:
Kobyakov D. S,Klimachev V. V,Avdalyan A. M,Bobrov I. P,Bychkova E. Yu
Abstract
The argirophilic proteins associated with nucleolar organizers areas (Ag-NOR) in adenocarcinomas of a lung were investigated. Coloring with nitrate silver was carried out according to the standardized protocol. Ag-NOR index area and variation coefficient were defined by the computer analysis of images. Statistically significant differences of Ag-NOR Square index for groups of indicators of T (only for T1), N, primary node 3 cm in size and more, disease stages (only for the I stage) and a tumor differentiation (only for high-differentiated) are received. The variation coefficient of Ag-NOR was statistically significant at differentiation of tumors up to 3 cm and more in high-differentiated moderated and low-differentiated adenocarcinomas. Coefficient determination of Ag-NOR protein variation is less significant in comparison with Ag-NOR Square by comparison of these data to morphological parameters of lung adenocarcinomas.
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