The role of growth factors in the pathogenesis of endometriosis

Abstract

Endometriosis is a chronic inflammatory hormone-dependent disease characterized by abnormal proliferation in the endometrium, nerves, blood vessels, fibroblasts, etc. and accompanied by immunological disorders. Growth factors are an important part of the mechanisms that underlie intercellular communication, auto- and paracrine regulation. This literature review presents data on abnormal expression of growth factors in patients with endometriosis, relationship of growth factors and hormonal status in normal and endometrial tissues, and the supposed role of growth factors in the pathogenesis of the disease.