Effect of reindeer pituitary peptide extract on cognitive functions in rats with changes light regime

Abstract

BACKGROUND: Disruption of circadian rhythms can cause significant damage to sensory processing, learning, and memory. At the same time, the structure of the endogenous biological clock contributes to the adaptation of the organism to changes in the conditions for the existence of a biosystem in the external environment. The possibility of synchronization of the endogenous rhythms of the organism with disturbed light periodicity is an urgent problem of modern society, where different rhythms of labor, motor, cognitive activity are used. AIM: To study the effect of peptides from the pituitary gland of the Reindeer on the parameters of cognitive functions in rats with a long-term change in the light regime on models with altered cellular oscillation due to oxidative stress caused by poisoning of animals with sodium thiopental in a half-lethal dose. MATERIALS AND METHODS: The study was conducted on 56 white Wistar male rats after acute poisoning with sodium thiopental at a dose of 85 mg/kg under conditions of light desynchronosis. In the passive avoidance conditioned reflex test, the cognitive functions of animals were assessed after a two-week pharmacological correction with a cellular extract of the pituitary gland of the Reindeer at a dose of 100 mg/kg. RESULTS: The peptide extract of the pituitary gland of the Reindeer contributes to the change in the higher integrative functions of the central nervous system in case of disturbed periodicity of the light signal. The results obtained indicate the chronobiotic activity of the peptide extract of the pituitary gland of the Reindeer at a dose of 100 g/kg when administered intranasally. CONCLUSIONS: The light regime change for 1 month under conditions of altered cellular oscillation led to impaired of the higher integrative functions of the central nervous system in rats, which was accompanied by an increase in the rate of reflex extinction and a disturbance of the processes of memory consolidation; under conditions of constant light, these disorders are more pronounced. The result of the pharmacological correction of these changes with the reindeer pituitary peptide extract was an improvement in the processes of memory consolidation and information reproduction (an increase in the number of trained animals with a change in the light regime).