The dynamics of morphological and functional changes of face neck skin at using injectables

Abstract

The article deals with the issues of face and neck skin involutional changes, which are considered to be the first and easily determined signs of the body aging. Clinical studies of the effectiveness of the therapy with medicines based on hyaluronic acid, silicon and zinc are presented. Based on the presented data, the possibility of further clinical trials of pharmacological preparations used to treat the skin of the face and neck is discussed. Of particular interest are data on the dynamics of expression of key biomarkers of skin aging in the combined use of silicon- and zinc-containing injectable drugs. The addition of zinc can enhance the effect of silicon compounds in the composition of these drugs. Organosilicon (silanol) increases the synthesis of type III collagen and elastin and has a protective effect against photodamage of the skin. An increase in the formation of type III collagen was revealed when using silicon complexes with chitinase, while an increase in the expression of TGF- and an increase in fibroblast proliferation were also revealed. The use of silicon- and zinc-containing drugs is a promising, but still insufficiently studied direction of therapy for involutional changes in the skin of the face and neck. Silicon and zinc in the composition of drugs for anti-aging therapy can have a synergistic effect, affecting a number of important molecular mechanisms of skin aging.