Abstract
Objective. To develop an accessible, easily reproducible, functional method for modeling bleeding from varicose veins of the esophagus based on the body of a laboratory animal.
Materials and methods. The work is based on an experiment carried out in the operating room of the vivarium of Ryazan State Medical University using laboratory animals 12 domestic pigs of the Large White breed.
Results. In 10 cases out of 12, it was possible to successfully form changes in the animal's body, allowing to provoke bleeding from the dilated veins of the esophagus, damaging them with biopsy forceps during fibroesophagoscopy.
Conclusions. Creation of an experimental model of bleeding from varicose veins of the esophagus in the body of a domestic pig by dosed clamping of the hepato-duodenal ligament with a plastic clamp, which was followed by subsequent damage of the esophageal veins with biopsy forceps during fibroesophagoscopy, is technically feasible, reliable, and the model itself is quite functional.
Reference6 articles.
1. Strizhakov A.N., Geradze V.N. The current state of the problem of liver cirrhosis. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii 2009; 2: 87–88 (in Russian).
2. Jupatov G.I., Prishhepenko V.A. Algorithm for the diagnosis and differential diagnosis of chronic diffuse liver diseases (chronic hepatitis and liver cirrhosis) in difficult clinical situations, based on the determination of the enzymatic activities of blood serum. Nauka molodykh (Eruditio Juvenium) 2020; 3: 566–573 (in Russian).
3. Zarivchatskiy M.F., Mugatarov I.N., Kamenskikh E.D. Prevention of bleeding from varicose veins of the esophagus and stomach in patients with liver cirrhosis. Permskiy meditsinskiy zhurnal 2009; 5: 5–14 (in Russian).
4. Shishin K.V., Nedoluzhko I.Yu. Endoscopic diagnosis, treatment and prevention of portal bleeding. Effektivnaya farmakoterapiya 2014; 43: 70–75 (in Russian).
5. Budko E.V., Chernikova D.A., Jampol'skij L.M. Local hemostatic agents and ways to improve them. Rossiyskiy mediko-biologicheskiy vestnik im. akademika I.P. Pavlova 2019; 2: 274–285 (in Russian).