Changes in Hip Chondrolysis. (Biopsy Study)

Abstract

Chondrolysis of hip joint as the complication of various diseases and injuries characterized by heterogeneous morphologic picture of the disorders including dystrophic, resorptive and lytic changes of the cartilage as well as inflammatory-sclerotic changes in subchondral bone lamina and joint capsule. Mechanism of destruction of the articular cartilage includes chondroresorption of superficial layers of the articular cartilage by hypercellular fibrous tissue (pannus), loosening, separation of fibers and lysis of cartilagenous matrix, sometimes with necrosis of superficial cartilagenous zone and subchondral bone lamina accompanied by chronic nonspecific inflammation. Activity of chondroosteoresorption resulting in articular cartilage destruction is higher during early term of chondrolysis (up to 1 year since the onset of the disease) and the longer the pathological process lasts, the higher is the degree of the cartilagenous matrix dystrophy.