Premature rupture of membranes in preterm pregnancy: prospects for prediction

Abstract

One of the major issues in modern midwifery is premature birth, which is often the result of premature rupture of membranes. Currently known methods for predicting premature rupture of membranes do not have sufficient predictive value in preterm pregnancy. This article summarizes modern views on the biochemical, immunological and microbiological aspects of the etiology and pathogenesis of premature rupture of membranes and premature birth. Further ways of searching for predictors of these complications are outlined herein.