New opportunities of therapeutic hyperthermia (literature review)

Abstract

An electronic search for publications on the results of the use of hyperthermia in medicine was carried out using the Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka,RSCI, international and regional journals, materials of international congresses, congresses and conferences. The review analyzes the results of experimental and clinical studies of the therapeutic effect of hyperthermia or in various non-inflammatory diseases. Experimental studies have shown a pronounced damaging effect of hyperthermia on some types of parasites and therapeutic effect on mice genetically predisposed to type 1 and 2 diabetes mellitus. Clinical studies have shown that hyperthermia significantly improves the condition of patients with cardiovascular and pulmonary insufficiency, depressive syndrome, chronic fatigue syndrome, psoriasis, benign prostatic hyperplasia, limb lymphedema, post-radiation fibrosis and Peyronie's disease. It has been shown that the effectiveness of hyperthermia is associated with a wide range of biological and physiological reactions of cells and tissues to heat exposure, including the expression of heat shock proteins. At the same time, the results obtained in an experiment and in a clinic without randomization require further research and confirmation.