Study of anticonvulsant properties of new antagonists of glutamate receptors

Abstract

The experimental data concerning anticonvulsant activity of new compounds, NMDA (IEM-1921, IEM-1791, IEM-2181) and AMPA (IEM-1460) antagonists, synthesized at the Dept. of NeuroPharmacology, in both NMDA and nicotine models of seizures reproduced in CBA mice are represented in the paper. The maximal anticonvulsant activity in a NMDA model was revealed for IEM-2181, an organic monosalt of alkylconstituted derivative of imidazole-4.5-lbcarbonic acid. IEM-2181 170 mg/kg completely blocked all seizure and behavioral signs of NMDA 170 mg/ kg administered intraperitoneally. At the same time, IEM-1460 (5 mg/kg), an antagonist of AMPA receptors, blocked seizures and behavioral hyperactivity induced by ip administration of nicotine (14 mg/kg). Thus, anticonvulsive activity of new antagonists of NMDA and AMPA receptors was established in models of NMDA and nicotine seizures.