The effect of taurine on state of experimental gestosis in rats

Abstract

BACKGROUND: Gestosis (preeclampsia) is an important problem of modern obstetrics. Despite the improvement of methods of prevention and treatment, there is an increase in the rate of this pregnancy complication. In this regard, the search for new approaches to the treatment of preeclampsia is an important problem of modern perinatology. AIM: The aim of this study is studying of the effect of taurine on experimental gestosis in rats. MATERIALS AND METHODS: Preeclampsia was induced on female rats by sodium nitrite and lipopolysaccharide. 2-aminoethanesulfonic acid was administered at a dose of 44.3 mg / kg (in terms of taurine) from the 16th to the 19th day of pregnancy. The number of implantation sites, resorption sites, live fetuses, weight of placentas and fetuses, lactate dehydrogenase activity, content of lactic and pyruvic acids, nitric oxide, malondialdehyde and creatine were evaluated. RESULTS: It has been shown that 2-aminoethanesulfonic acid leads to normalization of the metabolic processes (the level of malondialdehyde, nitric oxide, lactate and lactate dehydrogenase activity) in the body of pregnant female rats with induced preeclampsia in the last trimester of pregnancy. Taurine reduced the quantity of resorption, increased the weight of placentas and fetuses. Along with a correction of the lactate level, pyruvate and lactate dehydrogenase activity, it was observed a decrease of creatine level in placentas. CONCLUSIONS: Obtained results allows us to recommend taurine, which has antioxidant, antihypoxic, membrane stabilizing, detoxifying, osmoregulating and diuretic effects, for the treatment of placental disorders with preeclampsia.