Genotoxic properties of hypoglycemic drugs (systematic review)

Author:

Eremina Natalia V.ORCID,Zhanataev Aliy K.ORCID,Lisitsyn Artem A.ORCID,Durnev Andrey D.ORCID

Abstract

According to the literature genotoxic properties of about a half of hypoglycemic drugs have not been investigated in accordance with the recommended methodology, and studies of the mutagen-modifying activity of antidiabetic drugs are sporadic. Based on the available published data, it is impossible to conclude about either presence or absence of genotoxic / antigenotoxic potential of antidiabetic drugs. There is evidence of the antimutagenic activity of metformin; in relation to other drugs, studies of mutagen-modifying activity have not been carried out or are represented only by a few articles. Further study of the genotoxic properties of hypoglycemic drugs is required in accordance with modern approaches and requirements, as well as an assessment of their mutagen-modifying activity.

Publisher

ECO-Vector LLC

Subject

Genetics (clinical),Genetics,Ecology,Biochemistry,Ecology, Evolution, Behavior and Systematics

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