Clinical and pathogenetic significance of the microvascular component of bone tissue

Abstract

Bone tissues blood circulation and microcirculation are critical to its metabolic and reparative processes. Without the participation of the bone microcirculatory tissue system, it is difficult to exchange oxygen and carbon dioxide, transport of nutrients, and excrete metabolic products. The regeneration of bone tissue is characterized by the pairing of angiogenesis and osteogenesis, which allows the use of microcirculation indicators as additional criteria for the state of reparative processes. Non-invasive approaches for detecting the state of peripheral circulation and microcirculation, which would enable assessing the dynamics of the vascular factor in bone pathology, including after fractures, are most practical in the clinic.