Role of Kisspeptine in Regulation of Reproductive Function

Abstract

Research objective: to identify a role of kisspeptine in the regulation of reproduction function.Materials: literature data by foreign authors for the period from 1985 till 2016.Methods: systematic analysis and compilation of information in the literature.Results. The article provides a review of literature data on research of kisspeptine gene and its receptor; it includes description of their role in regulation of reproduction function and mutation in the genes responsible for realization of kisspeptine and neurokinin signaling pathways. Features of kisspeptine secretion in patients with hypogonadotropic hypogonadism, premature sexual development, hyperprolactinemic deficiency of ovaries, polycystic ovarian syndrome, genital endometriosis and opportunity of kisspeptine use in clinical practice as an ovulation trigger are described.Conclusion. It is necessary to carry out further studies for clarification of kisspeptine role in patients with various diseases and the opportunity of its use as a therapeutic target.