Angiogenesis in psoriasis as a therapeutic target (literature review)

Abstract

One of the characteristic features of psoriasis is increased vascularization in the psoriatic plaque. It is known that this process occurs as a result of pathological angiogenesis, which leads to an increase of blood vessels in the lesion, increased proliferation of endothelial cells, vasodilation and increased permeability of the vascular wall, facilitating penetration of immune cells and increasing inflammation. Many signaling molecules are involved in the process of angiogenesis in psoriasis. The most important indicator of the severity of pathological angiogenesis is endothelial vascular growth factor (VEGF). The issue of using blood serum analysis for endothelial vascular growth factor (VEGF) and diagnostic imaging techniques of the vascular network in psoriatic plaques to determine the severity of the process and the possibility of using additional treatment directions aimed at reducing vascularization is being considered. At the moment, the mechanisms of angiogenesis in psoriasis are being actively studied, and the possibilities of therapeutic influence on this link of pathogenesis are especially interesting. The authors present an analysis of the current literature on this topic, and suggest possible available treatment strategies based on the data obtained. Further research in this direction is needed to optimize the therapy of psoriasis, the main purpose of which will be to reduce the duration of treatment and prolong the time of remission.