Modern aspects of hemostasis state for fevers of rickettsiosis etiology

Abstract

To analyze the data obtained from scientific papers on Internet resources and to track the characteristic changes in hemostasis with various types of rickettsiosis fevers, allowing a better understanding of the pathogenesis of rickettsiosis and, as a result, a more competent approach to the treatment of this pathology. In the course of the work, numerous scientific papers of foreign and domestic scientists from various Internet resources (PubMed, CyberLeninka, Elibrari, etc.) were used, which made it possible to analyze changes in hemostasis and summarize them while working. At the end of the twentieth century, a rapid economic development of endemic zones caused changes in their nosology, significantly affecting an increase in the incidence of natural focal rickettsiosis from the group of tick-borne spotted fevers in many regions of the world. Geographical conditions of the Volga-Caspian floodplain have created optimal conditions for the formation of natural foci of some rickettsioses on the territory of the Astrakhan region. During the period of controlled epidemiological surveillance from 1983 to 2019, the incidence rate of Astrakhan rickettsia fever has increased several dozen times, the settlements located near the gas complex are hyperendemic. The results of numerous studies regarding infectious diseases of rickettsiosis etiology indicate the leading role of cellular structures in the imbalance of hemostasis suggesting a more detailed study of their functional activity and the determination of factors affecting their activity. Rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis of hemocoagulation disorders in the hemostasis system that formed the basis of this study. Thus, summing up all of the above, rickettsioses require a more thorough study of the clinical and epidemiological picture, pathogenetic aspects to identify criteria for early diagnosis and appointment of adequate therapy. The features of hemocoagulation dynamics in rickettsia fevers deserve special attention, because this process is both a trigger mechanism of the infectious process and an important factor affecting other structures of this biological system.