Glutamine and its derivatives in the correction of metabolic disorders in HIV-infected patients (review)

Abstract

It has been established that HIV-infection is associated with progressive deficiency of L-glutamine followed by immune dysfunction, reduced body mass and muscle strength, morphological disorders and functional disintegration of the intestine, as well as neurological disorders. According to current ideas, correction of L-glutamine deficiency is one of the important components of adjuvant therapy for HIV-infected patients within general nutritional support strategy. This measure helps to slow development of AIDS, reduce side effects of antiretroviral therapy and enhance effectiveness.