Possibilities of pharmacological correction of pathologies of gepatobiliarny system

Abstract

Diseases of the hepatobiliary system increase from year to year. Etiopathogenetic factors of liver lesion development are different, but in all cases of hepatopathies, despite a polietiologichnost of lesions, the treatment of a disease in general is referred on improvement of hepatocytes, and rather close pathogenetic therapy is for this purpose applied. Numerous researches reveal the leading role of an oxidative stress and, provoked by it, the perekisny oxidation of lipids of phospholipid membranes of hepatocytes provoked, by it in development of hepatopathies of any etiology. Taking into account a pathogenesis, of hepatopathies treatment of pathologies assumes an integrated approach. A specific place in the treatment of hepatopathies is held by gepatoprotektor - the means, which rise fastness of hepatocytes to the damaging factors. Today, n medical practice a series of gepatoprotektors of animals, plant and animal origin is used. By present time, are developed and studied a series of drugs of a plant origin, among which, the most often used, and well learned, are drugs of the sum of the flavonoids, received from a spotty thistle. Phytocomplexes for the purpose of their use for treatment and prophylaxis of development of the hepatopathies including caused by use of the medicinal preparations prescribed on vital indicators are framed and are investigated. The review of available literature showed, that despite the sufficient range of hepatoprotective drugs, today, the drugs conforming to clinical requirements no. In this regard search of new and modern highly effective medicines for treatment of the lesions of a liver of various etiology taking into account a development pathogenesis and which aren’t rendering undesirable side effects remains a current problem of medical science and practice. The leading direction is search of these means in group of substances with antioxidatic and antigipoksantny activity.