Isolated lobar arterio-portal liver perfusion in the experiment

Abstract

The study is devoted to topographic, anatomical and experimental justification of isolated lobar arterio-portal perfusion, the material for which served as liver preparations (n=28), explanted from the corpses of adult men and women who died at the age of 48 to 78 years as a result of injuries and diseases not associated with liver lesions and its major vessels, the data of radiographs of liver preparations (n=10), injected with x-ray contrast solutions, as well as selective angiograms (n=24) obtained with celiac topographic and anatomical features of the main vessels of the left lobe of the liver in relation to the problems of its isolated lobar arterio-portal perfusion are clarified. Based on the analysis of selective angiograms, obtained by clickography shown the absence of functioning vascular anastomoses between lobes of the liver. While further studies conducted on liver preparations (n=8), an experimental model of isolated lobar arterio-portal perfusion of the left lobe of the liver was developed. The approbation of this model convincingly confirmed the results obtained during anatomical studies. The peculiarity of the arterial and portal blood flow of the left surgical lobe of the liver is its isolation from the vascular arterio-portal basins of the right lobe of the liver. The experiment shows the possibility of isolated perfusion of the left lobe of the liver. The developed experimental model demonstrated the validity of the idea of isolated lobar arterio-portal perfusion of the left lobe of the liver and created favorable conditions for further improvement of the concept of retrograde isolated liver perfusion and the possibility of improving its technical aspects for further clinical testing in the complex treatment of patients with multiple bilobar metastatic liver damage.