ROLE OF HEMOSTATIC DISORDERS IN PNEUMONIA PROGRESS IN ACUTE PERIOD OF BURN DISEASE

Abstract

Pneumonia is not only the most frequent complication of burn patients, but also one of the leading causes of deaths as a result of this pathology. We have studied the system of hemocoagulation, endogenous anticoagulants and fibrinolysis in 136 patients with severe burns; in 69 patients, the burn disease was complicated by pneumonia and in 67 patients, it was not observed. Based on the totality of the laboratory tests results, it has been shown that pneumonia progress in the acute period of the burn disease was accompanied by high procoagulant activity, reduced levels of endogenous anticoagulants, fibrinolysis depression and moderate thrombocytopenia, severe hepatorenal failure indicating progress of the disseminated intravascular coagulation syndrome (DIC). Progress of acute DIC syndrome from 2 to 6 days after a burn can be not only an indirect evidence of pneumonia, but also can precede its clinical picture.