CORRELATION OF RECEPTORS’ EXTRACELLULAR POOL AND IMMUNE RESPONSE LEVEL IN INDIVIDUALS LIVING IN ARCTIC CONDITIONS

Abstract

The paper has presented data on the study of a relationship of activity of the immune response and the accumulation of a pool of free molecules involved in the processes of cell cooperation, activation of immune cells and their apoptosis in villagers of Revda, the Levozersky District of the Murmansk Region. The study has involved 91 people, 77 women and 14 men aged from 21 to 55 years. In order to study correlation levels of the immune response and a free pool of receptors, the initial values i n the database have been divided into samples with high and low contents of free and membrane-selectin ligand; free protein cell adhesion sCD324; transferrinfree and membrane transferrin receptors; apoptosis protein sAPO-1 / Fas ligand sFasL. In the examined patients, there have been found high concentrations of IgA and IgM, there have been detected signs of retardation of a switch in synthesis from antibodies IgM to IgG. The identified pattern indicates a special role of cellular interaction by way of L-selectin in realization of IgE antibody formation. Accumulation of free L-selectin occurred almost at all stages of the immune response development, as well as during the increase in the content of CEA, due to activation of process reactivity in the mucous barrier. There has not been established influence of free transferrin receptor (sCD71) on the content of the membrane receptor for transferrin (mCD71), transferrin, and immunoglobulins, was probably associated with 2-fold concentration of regulatory T-lymphocytes (SD45RA). Accumulation of the free pool of receptors involved in the reactions of apoptosis of the immune competent cells was manifested by decreased activity of B-lymphocytes apoptosis, thus prolonging the period of antibody formation.