Author:
Zashikhin A L,Lubeznova A Yu
Abstract
We have investigated reactivity of the smooth muscular tissue (SMT) of guinea pigs’ gall bladders in dynamics of acute cholecystitis development. Complex morphological, histochemical and immunohistochemical analyses have been carried out. During the disease development, the study has shown increased inflammatory phenomena of the mucosa in all parts of the gall bladders and a successive increase of the collagenic and elastic components of the intercellular matrix. The immunohistochemical analysis has shown that positive reaction of the smooth muscle cells to collagen type 1 was identified on the 15th day of the experiment. Thus, experimental dysfunction of the gall bladders caused reactive transformation of the SMT in which there was observed suppression of protein markers and activation of collagen synthesis.
Subject
General Medicine,Public Health, Environmental and Occupational Health,Ecology,Health (social science)
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