Efficacy and safety of new oral anticoagulants: Position of gastroenterologist

Abstract

The prevention of thromboembolism is the leading goal in the management of atrial fibrillation (AF) patients. Oral anticoagulants (OAC) has been using in the treatment of AF patients for a long time according the modern clinical recommendations. Recently, new direct oral anticoagulants (NOAC) have been increasingly used in the treatment and prevention of thrombo-embolism in AF patients. However, the problem of bleeding prevention in anticoagulated patients (primarily for gastrointestinal tract) is still unresolved. The authors analyzed the results of evidence-based medicine for assessing the risk of gastrointestinal bleeding in anticoagulated patients with NOACs. (For citation: Bakulin GI, Belousova LN, Pakhomova IG, Chizhova OYu. Efficacy and safety of new oral anticoagulants: Position of gastroenterologist. Herald of North-Western State Medical University named after I.I. Mechnikov. 2018;10(2):12-18. doi: 10.17816/mechnikov201810212-18).