The effect of β-endorphin on the functional parameters of the isolated heart and lymphatic vessels of the white rat

Abstract

Objective. The work is devoted to the comparison of the mechanisms of β-endorphin action in isolated rat heart and lymphatic vessels. Materials and methods. The experiments were performed using the Langendorff System perfusion device (Panlab, Spain) and the multichannel wire myograph 620M (DMT). During the study, selective opioid receptor blockers, K + channel blockers were used. Conclusion. In the course of experimental studies it was found that the most likely target for β-endorphin in an isolated rat heart are δ-opioid receptors, in isolated lymphatic vessels of a rat - μ- and δ-opioid receptors. The inhibitory effect of β-endorphin in the heart muscle is associated with stimulation of ATP-sensitive K + channels. In isolated lymphatic vessels, the effect of β-endorphin is realized through the activation of both potential-dependent and ATP-sensitive K+ channels.