Abstract
The current study analyzed Russian and foreign scientific evidence on oral mucosal regeneration published over the period between 2000 and 2020. The Central Scientific Medical Library, electronic Medical library (elibrary.ru), and the scientific database PubMed were searched for relevant experimental studies focusing on methods used to stimulate healing of excisional wounds in the palate. The aim of the review was to identify the most effective method of oral mucosal wound closure. The findings showed that the successful introduction of new methods for oral mucosal wound closure with reliable treatment outcomes was dependent on accurate experimental, laboratory, and histological substantiation of their effectiveness.