VLIYaNIE KOMBINIROVANNOY ANTIGIPERTENZIVNOY TERAPII NA PERFUZIYu GOLOVNOGO MOZGA I KOGNITIVNYKh FUNKTsIY U BOL'NYKh METABOLIChESKIM SINDROMOM-Reference-Cited by-同舟云学术

VLIYaNIE KOMBINIROVANNOY ANTIGIPERTENZIVNOY TERAPII NA PERFUZIYu GOLOVNOGO MOZGA I KOGNITIVNYKh FUNKTsIY U BOL'NYKh METABOLIChESKIM SINDROMOM

Published:2010-12-15 Issue:6 Volume:16 Page:7-11
ISSN:2412-9100
Container-title:Russian Medicine
language:
Short-container-title:Russian Medicine

Author:

Efimova Irina Yur'evna¹,Mananko E I²,Efimova N Yu¹,Idrisova E M²,Lishmanov Yu B¹

Affiliation:

1. Учреждение Российской академии медицинских наук Научно-исследовательский институт кардиологии Сибирского отделения РАМН

2. ГОУ ВПО Сибирский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию

Abstract

The purpose of the study was to evaluate brain perfusion and cognitive function (CF) in patients with metabolic syndrome (MS) during combination antihypertensive therapy. Twenty-four patients with MS underwent brain single-photon emission computed tomography using 99mTc-hexamethylpropylenamine oxime (HMPAO) and their CF were determined before and 6 months after antihypertensive therapy with enalapril in combination of long-acting nifedipine or moxonidine. Brain tomoscintigraphy showed that before treatment the patients with MS exhibited both areas of lower accumulation of 99mTc-HMPAO (hypoperfusion) and those with higher accumulation of this indicator (hyperperfusion) than did the controls. Six-month antihypertensive therapy with enalapril in combination with long-acting nifedipine or moxonidine leads to optimization of brain blood supply and CF improvement in patients with MS.

Publisher

ECO-Vector LLC

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