Abstract
Placental in-growth is a severe obstetric pathology characterized by invasive placentation and associated with a high-risk of life-threatening hemorrhage. Despite the widespread use of instrumental methods of examination, timely diagnosis of placental in-growth is a challenging issue. Here, we reviewed the existing biochemical markers used for early detection and confirmation of placental in-growth, their specificity and sensitivity, and correlation with gestational age. Significant results were found for the following substances: pregnancy-associated plasma protein A (PAPP-A) in the first trimester, alpha-fetoprotein (AFP) and human beta-chorionic gonadotropin (Beta-hCG) in the second trimester, brain natriuretic peptide, antithrombin III, plasminogen activator inhibitor type I, soluble Tie-2 receptor (endothelial cell-specific tyrosine kinase receptor), and soluble vascular endothelial growth factor receptor-2. Our findings support the use of the aforementioned biomarkers as screening method for placental in-growth in medical practice.
Reference41 articles.
1. Committee Opinion No. 529
2. Real increasing incidence of hysterectomy for placenta accreta following previous caesarean section
3. Multiple Repeat Cesareans and the Threat of Placenta Accreta: Incidence, Diagnosis, Management
4. Polikarpov AV, Aleksandrova GA, Golubev NA, et al. Main indicators of maternal and child health, the service activities of child welfare and obstetrics in the Russian Federation. Moscow; 2018. (In Russ).
5. Polikarpov AV, Aleksandrova GA, Golubev NA, et al. Main indicators of maternal and child health, the service activities of child welfare and obstetrics in the Russian Federation. Moscow; 2019. (In Russ).