Abstract
The objective of this review was to systematize current data on the -adrenoblockers (-ABs) used in the treatment of cardiovascular diseases and to analyze the results of studies performed with a focus on metoprolol succinate controlled release/extended release (CR/XL) formulation. The article addresses issues related to pharmacological features of metoprolol succinate CR/XL, the use of -AB in arterial hypertension, coronary heart disease, chronic heart failure, and cardiac arrhythmias based on international and Russian clinical guidelines. Results of randomized clinical trials evaluating the efficacy of metoprolol succinate CR/XL are presented. In preparing the literature review, a review of publications over the past 34 years in the MEDLINE/PubMed, Scopus, Cochrane Library, eLIBRARY, and Google Scholar databases was performed. The presented data indicate the need for more extensive use of -ABs, including metoprolol succinate CR/XL, in clinical practice.
Reference55 articles.
1. Controlled Release Metoprolol Formulations
2. Белоусов Ю.Б., Леонова М.В., Машенина О.А., и др. Метопролола сукцинат и тартрат: влияет ли соль на эффективность препарата. Фарматека. 2006;19:14-9 [Belousov YuB, Leonova MV, Mashenina OA, et al. Metoprolol succinate and tartratе: does salt affect on the effectiveness of the drug. Farmateca. 2006;19:14-9 (in Russian)].
3. Metoprolol
4. Pharmacokinetic and pharmacodynamic properties of a new controlled-release formulation of metoprolol: A comparison with conventional tablets
5. Pharmacokinetic and pharmacodynamic comparison of a new controlled-release formulation of metoprolol with a traditional slow-release formulation
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献