Pathogenetic Aspects of Bronchial Asthma Phenotyping

Abstract

INTRODUCTION: During a many-year history of its study, bronchial asthma (BA) has gone through the stages of numerous classifications. The introduction of specific biological therapy of BA permitted to speak about the phenotypes of the disease. AIM: Presentation of the main pathophysiological mechanisms for isolation of endotypes and phenotypes of BA. The diagnosis of phenotype of BA is based on the pathophysiological mechanisms of its development, which permit to evaluate the dynamics of the disease, make the diagnosis and predict the course of the disease. The most complicated aspect of BA phenotyping is severe forms of the disease characterized by a combination of different phenotypes. This impedes evaluation of specific pathogenetic mechanisms and administration of the optimal therapy for the patient. CONCLUSION: The diagnosis of BA phenotypes permits to identify specific pathogenetic mechanisms and thereby personalize the treatment.