The Role and Significance of Polymorphisms of Certain Genes in Patients with Abdominal Aortic Aneurysm

Author:

Kalmykov EganORCID,Suchkov Igor’ A.ORCID,Kalinin Roman E.ORCID,Ne’matzoda OkildyhonORCID,Dodkhoev Jamshed S.ORCID

Abstract

INTRODUCTION: To date, many factors that influence the risk and course of abdominal aortic aneurysm (AAA) are not studied. Increasing significance in the etiology and development of AAA is assigned to the existence of some genetic polymorphisms, the role of many of them is not studied either. AIM: To analyze the existence of association of the abdominal aortic aneurysm with some gene polymorphisms (GPs). MATERIALS AND METHODS: Gene polymorphisms were analyzed in 20 patients with AAA (study group, SG); 18 men (90%) and 2 women (10%), the mean age 68.1 7.3 years), and in 5 patients without AAA (control group, CG; 4 men (80%) and 1 woman (20%), the mean age 64.2 7.2 years). The frequency of concomitant diseases and risk factors for AAA were determined. The following GPs were studied: : Lys198Asn in the EDN1 gene; C-786T in the NOS3 gene; Leu28Pro in the APOE gene; Val174Ala in the SLC01B1 gene; Thr715Pro in the SELP gene; C807T in the ITGA2 gene; Ser447Ter in the LpL gene; Thr174Met in the AGT gene; Met235Thr in the AGT gene. Statistical analysis was performed using IBM SPSS Statistics 21, correlation analysis ― according to Pearson. The results were considered statistically significant at p 0.05. RESULTS: In the SG, correlation relationships were identified in Ser447Ter polymorphism in the LpL gene: direct relationships with Lys198Asn polymorphism (r = 0.63; р 0.001) in the EDN1 gene, Leu28Pro (r = 0.70; р 0.001) in the APOE gene and Thr715Pro (r = 0.63; р 0.001) in the SELP gene; a reverse relationship with С786Т polymorphism (r = -0.35; р = 0.006) in the NOS3 gene. The same amount of relationships were found in Leu28Pro polymorphism in the APOE gene: besides with Ser447Ter in the LpL gene, there is also a direct relationship with Lys198Asn (r = 0.70; р 0.001) in the EDN1 gene and Thr715Pro (r = 0.63; р 0.001) in the SELP gene; a reverse relationship with С786Т (r = -0.35; р = 0.006) in the NOS3 gene. Thr715Pro polymorphism in the SELP gene, along with relationships with Ser447Ter (r = 0.63; р 0.001) in the LpL gene and Leu28Pro in the APOE gene, has an additional direct relationship with Lys198Asn (r = 0.55; р 0.001) in the EDN1 gene. Thr174Met polymorphism in the AGT gene has a reverse relationship with Leu28Pro (r = -0.35; р = 0.006) in the APOE gene and direct relationship with Val174Ala (r = 0.40; р = 0.002) in the SLC01B1 gene. With this, Met235Thr polymorphism in the AGT gene has a direct relationship with Val174Ala (r = 0.33; p = 0.011) in the SLC01B1 gene and reverse relationship with C807T in the ITGA2 gene. CONCLUSION: The existence of direct correlations of some gene polymorphisms in patients with abdominal aortic aneurysm has been established, which indicates their probable role in the development of this pathology and may be used as a screening test for determination of the likelihood for its development.

Publisher

ECO-Vector LLC

Subject

General Medicine

Reference12 articles.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Experience in Treatment of Patients with First Type Secondary Endoleaks;I.P. Pavlov Russian Medical Biological Herald;2023-10-12

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3