Modern approaches to optimizing engraftment of free vascularized autografts (literature review and own data)

Abstract

Despite the high level of engraftment of free vascularized autografts (SVA), the frequency of postoperative complications (marginal necrosis, including due to hematomas, secondary infection, edema and tissue tension, compression of the vascular pedicle, thrombosis of vascular anastomoses) is 20% or more [4] . In our opinion, the main ways to optimize the engraftment of SVA are not only the prevention of technical errors during and after the operation, but also the development of tactics for the pharmacological prevention of tissue death at the postischemic reperfusion stage, taking into account the most significant pathogenesis factors that are relatively independent of the individual course of the postoperative period.