Immune response in neuroinflammatory caused by mild traumatic brain injury (experimental study)-Reference-Cited by-同舟云学术

Immune response in neuroinflammatory caused by mild traumatic brain injury (experimental study)

Published:2023-11-16 Issue:1-4 Volume:19 Page:54-60
ISSN:1684-7849
Container-title:Cytokines and inflammation
language:
Short-container-title:Cytokines and inflammation

Author:

Rad’kov Ivan V.,Plekhova Natalia G.,Zinoviev Sergey V.,Shumatov Valentin B.

Abstract

The study of the organism immune response in mild traumatic brain injury (mTBI) is an important stage in the formation of a scientific understanding of this type of brain damage. The purpose of the study: to research of the systemic immune response parameters in the experimental modeling of mTBI. The cellular composition and phenotype of immune cell subpopulations were assessed, and the content of pro- and anti-inflammatory cytokines in the mTBI and blood serum of injured rats was determined. A high content of leukocytes and interleukin 6 (IL 6) in the blood was found 2 hours after the injury. The number of cytotoxic T-lymphocytes and B-lymphocytes increased with a decrease of the neutrophils, monocytes, eosinophils and T helpers number one day after mTBI. During the indicated periods of observation, an increase in the content of cytokines TNF and IL 6 in the cerebrospinal fluid and blood serum was observed, and the indicators of anti-inflammatory IL 10 increased 714 days after mTBI. On the 14th day after injury, the level of stab neutrophils remained low, while the number of CD45, CD3, CD20, and CD8 positive lymphocytes continued to increase, which indicates the progression of the inflammatory response. Thus, after the application of mTBI, an inflammatory reaction develops, accompanied by the manifestation of the activity of immune components. Cytokines are registered in the peripheral circulation and cerebrospinal fluid, the number of B-lymphocytes and cytotoxic T-lymphocytes increases.

Publisher

ECO-Vector LLC

Reference19 articles.

1. Колесникова А.А., Флейшман М.Ю., Якушева Н.Ю., Слободенюк Е.В., Толстенок И.В. Уровень окислительного стресса в ткани мозга крыс после черепномозговой травмы при введении синтетических регуляторных пептидов // Тихоокеанский медицинский журнал. – 2020. – Т. 3. – С. 65-67.

2. Kolesnikova A.A., Fleishman M.Yu., Yakusheva N.Yu., Slobodenyuk E.V., Tolstenok I.V. [The level of oxidative stress in rat brain tissue after a brain trauma injury with introduction of synthetic regulatory peptides] // Pacific Medical Journal. 2020. Vol. 3. P. 65-67. (Russian)

3. Мамытова Э.М., Майназарова Э.С., Жусупова А.Т. Особенности иммунных нарушений в остром периоде черепно-мозговой травмы // Вестник КРСУ. – 2014. – Т. 14, № 4. – С. 120–123.

4. Mamytova E.M., Mainazarova E.S., Zhusupova A.T. Features of immune disorders in the acute period of traumatic brain injury // Vestnik KRSU. 2014. T.14. No. 4. P.120–123.

5. Плехова Н.Г., Зиновьев С.В., Дюйзен И.В., Барышев А.Н., Шуматов В.Б. Поведенческая реакция животных и морфологическая структура неокортекса при экспериментальной черепно-мозговой травме лёгкой степени // Бюлл. эксп. биол. и мед. – 2020. – Т. 170, № 11. – С. 640-645.