Abstract
BACKGROUND: The present study is an actual one because up to now there are no standards for craniosynostosis diagnostics and no simple and safe techniques for it. Osteocalcin concentration in the blood serum is an important marker of bone metabolism, that is why this parameter was chosen as a potential laboratory marker of craniosynostosis.
AIM: To determine osteocalcin concentrations in the blood serum of children with various forms of craniosynostosis.
METHODS: 94 children with craniosynostosis who were treated in the pediatric neurosurgical department of the Federal Center for Neurosurgery of the Ministry of Health of the Russian Federation (Novosibirsk, Russia) from November 2018 to March 2022 were included in the trail. Inclusion criteria were: age up to 6 complete years, children with syndromic and non-syndromic forms of craniosynostosis. The obtained findings were analyzed in two age groups: up to 6 months and over 6 months because of different reference values.
RESULTS: 8 children out of 60, aged 6 months-6 years, had the increased osteocalcin concentration in the serum (13.3%).
CONCLUSION: No correlation has been revealed between craniosynostosis and increased serum osteocalcin concentrations in children under 6 years of age.