Chondrosarcoma in Children

Abstract

Treatment experience was analyzed in 77 patients (aged from 1 to 17 years) with chondrosarcoma. All patients were under treatment at the Scientific Research Institute of Pediatric Oncology and Hematology during the period from 1982 to 2008. In 36 patients including patients with second degree of malignancy (main group) new treatment protocol that provided application of polychemotherapy with regard to the risk group was used. Second degree of malignancy was determined by the degree of DNA ploidy and proliferative tumor cells activity by flow cytophotometry data. Forty one patients (control group) were treated according to the routine protocol. It has been shown that early application of polychemotherapy enabled to expand the indications to organ saving surgical interventions and to increase 5-years relapse-free survival at unfavo-rable forms of chondrosarcoma up to 75±7.8%.