Analysis of the content of mineral elements in connective tissues in patients with bisphosphonate osteonecrosis

Abstract

BACKGROUND: The presence of a large number of pathological studies and a significant amount of literature on high bone density in patients with bisphosphonate osteonecrosis determined the conduct of this study. AIM: To monitor micro- and macronutrients in patients with bisphosphonate osteonecrosis of the jaws, to detail their role in the pathological process. MATERIALS AND METHODS: In 184 patients with bisphosphonate necrosis, after sequestrectomy, the micro- and macronutrient composition of bone fragments removed from the lesion was analyzed. RESULTS: Deviations from reference values were found in such elements as sulfur (S2-), chlorine (Cl-), potassium (K+), calcium (Ca2+), phosphorus (P3+). The dynamics of micro- and macronutrients correlated with the clinical picture of the pathological process under study and the number of sessions or courses of adjuvant therapy. CONCLUSION: It is assumed that violations of cascade physiological reactions that develop as a result of violations of the mineral composition in the connective tissue are due to the pharmacokinetic properties of bisphosphonate preparations. The study of a number of micro- and macronutrients is predetermined by their role in the life and functional activity of amino acids, enzymatic systems, importance in the structure of cells and tissues.