HLA complex antigens at infantile cerebral paralysis in Kazan population

Abstract

A complex clinico-instrumental and immunogenetic study has been performed in 34 patients with different forms of infantile cerebral palsy in Kazan population. HLA-typing has revealed a reliable disease association with antigen B13. The control group was made up of 115 healthy patients. For the first time a comparable risk criteria has been counted: if a patient has B13 antigen risk of infantile cerebral paralysis development increases by 3.55 times. Contribution of HLA-B13 associated gene into genesis of the disease makes up not less than 11,6%. The study results testify to heridatary mechanisms envolvement into etiopathogenesis of infantile cerebral paralysis and demand further study of genetic peculiarities of susceptibility genome to different harmful factors.