Role of key endocannabinoids and their receptors in breast cancer-Reference-Cited by-同舟云学术

Role of key endocannabinoids and their receptors in breast cancer

Published:2024-04-27 Issue:1 Volume:22 Page:41-51
ISSN:2542-1875
Container-title:Reviews on Clinical Pharmacology and Drug Therapy
language:
Short-container-title:Rev Clin Pharm Drug Ther

Author:

Akimov Mikhail G.¹^ORCID,Dudina Polina V.¹^ORCID,Vyunova Tatiana V.²^ORCID,Kalueff Allan V.³⁴⁵⁶⁷^ORCID,Gretskaya Natalia M.¹^ORCID,Bezuglov Vladimir V.¹^ORCID

Affiliation:

1. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

2. Life Improvement by Future Technologies “LIFT” Center

3. Sirius University of Science and Technology

4. Almazov National Medical Research Centre

5. Saint Petersburg State University

6. Granov Russian Research Center of Radiology and Surgical Technologies

7. Ural Federal University

Abstract

Breast cancer stands as the leading cause of cancer-related deaths among women worldwide. Endocannabinoids and their exogenous analogs, e.g., tetrahydrocannabinol, exhibit antitumor effects in various animal models of cancer. However, several studies have shown that under certain conditions, treatment with cannabinoids can stimulate the proliferation of cancer cells in vitro and disrupt the immune system’s involvement in suppressing tumors. Additionally, conflicting reports exist regarding the antitumor role of endocannabinoid system in cancer. This review aims to consider the main mechanisms of action of key ligands and receptors of the endocannabinoid system within the context of breast cancer.

Publisher

ECO-Vector LLC

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