Respiratory epithelium and airway hyperresponsiveness

Abstract

The main and obligatory link in the pathogenesis of bronchial asthma (BA) is bronchial hyperreactivity. Analysis of the reasons leading to its formation in BA patients made it possible to divide them into two large groups: 1) environmental factors that allergize the patient and alter the reactivity of the bronchi; 2) environmental factors that directly affect the bronchi with subsequent changes in reactivity (chemical and mechanical irritants, physical and meteorological factors).