DEFENSE MECHANISMS OF THE SURFACE EPITHELIUM OF HUMAN ESOPHAGEALMUCOSA-Reference-Cited by-同舟云学术

DEFENSE MECHANISMS OF THE SURFACE EPITHELIUM OF HUMAN ESOPHAGEALMUCOSA

Published:2006-12-15 Issue:6 Volume:130 Page:12-24
ISSN:2949-2556
Container-title:Morphology
language:
Short-container-title:Morphology

Author:

Bykov V L,Iseeva E A,Bykov V L,Iseyeva Ye A

Abstract

This review, which is based on the literature data and the results of personal research, contains an analysis of the current concepts on the tissue, cellular and molecular mechanisms, protecting human esophageal epithelium (EE) from gastric juice, bile, hot and rough food, microorganisms, alcohol, carcinogens, drugs and oxidizing agents. The response of EE to concrete environmental factors includes both specific and non-specific components, which depend on the nature of injurious agent. EE is damaged structurally and functionally only when it is exposed to the injurious factors of high intensity and /or long duration, which result in the exhaustion of resources of defense mechanisms. The insufficiency of EE defense mechanisms may be based on various genetic defects.

Publisher

ECO-Vector LLC

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