Urinary biomarkers in children with kidney diseases taking into account obesity

Abstract

BACKGROUND: Overweight and obesity in children are one of the most serious problems of the modern world. There are mane publications devoted to kidney injury in patients with obesity. This injury in developed imperceptibly, without clinical symptoms. Probably the diagnostics of kidney injury in children with obesity may be improved by studying new urinary markers: KIM-1, NGAL, IL-18, 2-mg. AIM: Aim of our study was the comparative analysis of urinary markers of tubular kidney injury (KIM-1, NGAL, IL-18, 2-mg) in children with obesity and kidney diseases. MATERIALS AND METHODS: We have been studied 78 children aged 715 years: 40 children with different kidney diseases and 38 patients with obesity and kidney diseases. The results of the study were presented as markers concentration in urine and as relation to creatinine (normalized indicators). RESULTS: In children with obesity and kidney diseases the level of KIM-1 was more high in comparison with the children without obesity. The concentration of other markers (NGAL, IL-18, 2-mg) did not differ in children of two groups. The same results were received when analyzing normalized indicators. It was appeared significant correlation between body mass of patients and NGAL of urine in both groups. CONCLUSIONS: Investigation of urinary KIM-1 have significance for diagnostics of tubular kidney injury in children with obesity on the background of kidney diseases. Established significant correlation NGAL with body mass can testify about it is diagnostic significance for obesity regardless of kidney diseases.