Obicetrapib: There is still Life in the CETP Inhibitor!
Author:
Affiliation:
1. Department of Clinical Laboratory Technology, Faculty of Medical Science, Juntendo University
Publisher
Japan Atherosclerosis Society
Link
https://www.jstage.jst.go.jp/article/jat/advpub/0/advpub_ED265/_pdf
Reference10 articles.
1. 1) Ogura M. HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism. J Pharmacol Sci, 2022; 150: 81-89
2. 2) Harada-Shiba M, Davidson MH, Ditmarsch M, Hseih A, Wuerdeman E, Kling D, Nield A, Dicklin MR, Nakata A, Sueyoshi A, Kuroyanagi S, Kastelein JJP. Obicetrapib as an Adjunct to Stable Statin Therapy in Japanese Subjects: Results from a Randomized Phase 2 Trial. J Atheroscler Thromb, 2024; in press. doi: https://doi.org/10.5551/jat.64828
3. 3) Kastelein JJP, Hseih A, Dicklin MR, Ditmarsch M, Davidson MH. Obicetrapib: Reversing the Tide of CETP Inhibitor Disappointments. Curr Atheroscler Rep, 2024; 26: 35-44
4. 4) Hovingh GK, Kastelein JJ, van Deventer SJ, Round P, Ford J, Saleheen D, Rader DJ, Brewer HB, Barter PJ. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet, 2015; 386: 452-460
5. 5) Nicholls SJ, Ditmarsch M, Kastelein JJ, Rigby SP, Kling D, Curcio DL, Alp NJ, Davidson MH. Lipid lowering effects of the CETP inhibitor obicetrapib in combination with high-intensity statins: a randomized phase 2 trial. Nat Med, 2022; 28: 1672-1678
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