Cholesterol Crystals as the Main Trigger of Interleukin-6 Production through Innate Inflammatory Response in Human Spontaneously Ruptured Aortic Plaques
Author:
Affiliation:
1. Department of Cardiology, Cardiovascular Center, Osaka Gyoumeikan Hospital
2. Department of Medical Technology, Morinomiya University of Medical Sciences
3. Division of Pathology, Cardiovascular Center, Osaka Gyoumeikan Hospital
Publisher
Japan Atherosclerosis Society
Subject
Biochemistry (medical),Cardiology and Cardiovascular Medicine,Internal Medicine
Link
https://www.jstage.jst.go.jp/article/jat/30/11/30_64098/_pdf
Reference28 articles.
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2. 2) Jang IK, Lassila R, Fuster V. Atherogenesis and inflammation. Eur Heart J, 1993; 14 Suppl K: 2-6
3. 3) Nidorf SM, Fiolet A, Abela GS. Viewing atherosclerosis through a crystal lens: How the evolving structure of cholesterol crystals in atherosclerotic plaque alters its stability. J Clin Lipidol, 2020; 14: 619-630
4. 4) Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature, 2010; 464: 1357-1361
5. 5) Abela GS, Aziz K. Cholesterol crystals rupture biological membranes and human plaques during acute cardiovascular events--a novel insight into plaque rupture by scanning electron microscopy. Scanning, 2006; 28: 1-10
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