Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial

Author:

Gewalt Senta1,Lahu Shqipdona1,Ndrepepa Gjin1,Pellegrini Costanza1,Bernlochner Isabell23,Neumann Franz-Josef4,Menichelli Maurizio5,Morath Tanja1,Witzenbichler Bernhard6,Wöhrle Jochen7,Hoppe Katharina1,Richardt Gert8,Laugwitz Karl-Ludwig23,Schunkert Heribert12,Kastrati Adnan12,Schüpke Stefanie12,Mayer Katharina1

Affiliation:

1. Deutsches Herzzentrum München, Cardiology, and Technische Universität München

2. German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance

3. Medizinische Klinik und Poliklinik Innere Medizin I (Kardiologie, Angiologie, Pneumologie), Klinikum rechts der Isar

4. Department of Cardiology and Angiology II, University Heart Center Freiburg · Bad Krozingen

5. Ospedale Fabrizio Spaziani, Cardiology

6. Helios Amper-Klinikum Dachau, Cardiology & Pneumology

7. Department of Cardiology, Medical Campus Lake Constance

8. Heart Center Bad Segeberg

Publisher

Japan Atherosclerosis Society

Subject

Biochemistry (medical),Cardiology and Cardiovascular Medicine,Internal Medicine

Reference31 articles.

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2. 2) Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED, Investigators C. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Circulation, 2006; 114: 1380-1387

3. 3) Chandrasekhar J, Baber U, Sartori S, Faggioni M, Aquino M, Kini A, Weintraub W, Rao S, Kapadia S, Weiss S, Strauss C, Toma C, Muhlestein B, DeFranco A, Effron M, Keller S, Baker B, Pocock S, Henry T, Mehran R. Sex-related differences in outcomes among men and women under 55 years of age with acute coronary syndrome undergoing percutaneous coronary intervention: Results from the PROMETHEUS study. Catheter Cardiovasc Interv, 2017; 89: 629-637

4. 4) Wang TY, Angiolillo DJ, Cushman M, Sabatine MS, Bray PF, Smyth SS, Dauerman HL, French PA, Becker RC. Platelet biology and response to antiplatelet therapy in women: implications for the development and use of antiplatelet pharmacotherapies for cardiovascular disease. J Am Coll Cardiol, 2012; 59: 891-900

5. 5) Patti G, De Caterina R, Abbate R, Andreotti F, Biasucci LM, Calabro P, Cioni G, Davi G, Di Sciascio G, Golia E, Golino P, Malatesta G, Mangiacapra F, Marcucci R, Nusca A, Parato VM, Pengo V, Prisco D, Pulcinelli F, Renda G, Ricottini E, Ruggieri B, Santilli F, Sofi F, Zimarino M, Working Group on Thrombosis of the Italian Society of C. Platelet function and long-term antiplatelet therapy in women: is there a gender-specificity? A ‘state-of-the-art' paper. Eur Heart J, 2014; 35: 2213-2223b

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