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Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study

  • Published:2024-07-01 Issue:7 Volume:31 Page:1058-1071
  • ISSN:1340-3478
  • Container-title:Journal of Atherosclerosis and Thrombosis
  • language:en
  • Short-container-title:JAT

Author:

Kujala Iida1,Vangipurapu Jagadish2,Maaniitty Teemu13,Saraste Antti14,Kere Juha56,Knuuti Juhani13

Affiliation:

1. Turku PET Centre, Turku University Hospital and University of Turku

2. Institute of Clinical Medicine, University of Eastern Finland

3. Department of clinical physiology, nuclear medicine and PET, Turku University Hospital

4. Heart Center, Turku University Hospital and University of Turku

5. Department of Biosciences and Nutrition, Karolinska Institutet

6. Folkhalsan Research Center, and Stem Cells and Metabolism Research Program, University of Helsinki

Publisher

Japan Atherosclerosis Society

Reference21 articles.

1. 1) Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, Chamberlain AM, Chang AR, Cheng S, Delling FN, Djousse L, Elkind MSV, Ferguson JF, Fornage M, Khan SS, Kissela BM, Knutson KL, Kwan TW, Lackland DT, Lewis TT, Lichtman JH, Longenecker CT, Loop MS, Lutsey PL, Martin SS, Matsushita K, Moran AE, Mussolino ME, Perak AM, Rosamond WD, Roth GA, Sampson UKA, Satou GM, Schroeder EB, Shah SH, Shay CM, Spartano NL, Stokes A, Tirschwell DL, VanWagner LB, Tsao CW; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2020 Update: A Report From the American Heart Association. Circulation, 2020 3; 141: e139-e596

2. 2) Khera AV, Chaffin M, Aragam KG, Haas ME, Roselli C, Choi SH, Natarajan P, Lander ES, Lubitz SA, Ellinor PT, Kathiresan S. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet, 2018 ; 50: 1219-1224

3. 3) Agbaedeng TA, Noubiap JJ, Mofo Mato EP, Chew DP, Figtree GA, Said MA, van der Harst P. Polygenic risk score and coronary artery disease: A meta-analysis of 979,286 participant data. Atherosclerosis, 2021; 333: 48-55

4. 4) Elliott J, Bodinier B, Bond TA, Chadeau-Hyam M, Evangelou E, Moons KGM, Dehghan A, Muller DC, Elliott P, Tzoulaki I. Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease. JAMA, 2020 18; 323: 636-645

5. 5) Mars N, Koskela JT, Ripatti P, Kiiskinen TTJ, Havulinna AS, Lindbohm JV, Ahola-Olli A, Kurki M, Karjalainen J, Palta P; FinnGen; Neale BM, Daly M, Salomaa V, Palotie A, Widén E, Ripatti S. Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers. Nat Med, 2020; 26: 549-557

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