Unexpectedly High Prevalence of Acquired von Willebrand Syndrome in Patients with Severe Aortic Stenosis as Evaluated with a Novel Large Multimer Index

Author:

Tamura Toshihiro1,Horiuchi Hisanori2,Imai Masao3,Tada Tomohisa4,Shiomi Hiroki3,Kuroda Maiko1,Nishimura Shunsuke1,Takahashi Yusuke1,Yoshikawa Yusuke1,Tsujimura Akira1,Amano Masashi1,Hayama Yukiko1,Imamura Sari1,Onishi Naoaki1,Tamaki Yodo1,Enomoto Soichiro1,Miyake Makoto1,Kondo Hirokazu1,Kaitani Kazuaki1,Izumi Chisato1,Kimura Takeshi3,Nakagawa Yoshihisa1

Affiliation:

1. Department of Cardiology, Tenri Hospital

2. Department of Molecular and Cellular Biology, Institute of Development, Aging and Cancer, Tohoku University

3. Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

4. Department of Cardiovascular Medicine, Shizuoka General Hospital

Publisher

Japan Atherosclerosis Society

Subject

Biochemistry, medical,Cardiology and Cardiovascular Medicine,Internal Medicine

Reference19 articles.

1. 1) Alec V, Ottavio A, Felicita A, Manuel JA, Gonzalo BE, Helmut B, Michael A, Thierry PC, Michele DB, Arturo E, Volkmar F, Bernard I, Patrizio L, Luc P, Susanna P, Hans-Joachim S, Gerhard S, Janina S, Karl S, Johanna T, Ulrich OVO, Stephan W, Jose LZ, Marian Z: Guidelines on the management of valvular heart disease: The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J, 2012; 33: 2451-2496

2. 2) Heyde EC: Gastrointestinal bleeding in aortic stenosis. N Engl J Med, 1958; 259: 196

3. 3) Loscalzo J: From clinical observation to mechanism--Heyde's syndrome. N Engl J Med, 2012; 367: 1954-1956

4. 4) Sandra Haberichter RM: Structure and function of von Willebrand factor. V. Marder, W. Aird, J. Bennett, S. Schulman, G. White II editor. Hemostasis and Thrombosis, 6th edn. 2013; 197-207

5. 5) Furlan M, Robles R, Solenthaler M, Wassmer M, Sandoz P, Lammle B: Deficient activity of von Willebrand factorcleaving protease in chronic relapsing thrombotic thrombocytopenic purpura. Blood, 1997; 89: 3097-3103

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