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Intravenous Alteplase at 0.6 mg/kg for Unknown Onset Stroke with Prior Antithrombotic Medication: THAWS Randomized Clinical Trial

  • Published:2023-01-01 Issue:1 Volume:30 Page:15-22
  • ISSN:1340-3478
  • Container-title:Journal of Atherosclerosis and Thrombosis
  • language:en
  • Short-container-title:JAT

Author:

Koga Masatoshi1,Inoue Manabu1,Miwa Kaori1,Yoshimura Sohei1,Fukuda-Doi Mayumi2,Aoki Junya3,Asakura Koko2,Kanzawa Takao4,Ohtaki Masafumi5,Kamiyama Kenji6,Yakushiji Yusuke7,Igarashi Shuichi8,Doijiri Ryosuke9,Ito Yasuhiro10,Takagi Yasushi11,Sasaki Makoto12,Kitazono Takanari13,Kimura Kazumi3,Minematsu Kazuo14,Yamamoto Haruko2,Toyoda Kazunori1

Affiliation:

1. Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center

2. Department of Data Science, National Cerebral and Cardiovascular Center

3. Department of Neurology, Graduate School of Medicine, Nippon Medical School

4. Department of Stroke Medicine, Institute of Brain and Blood Vessels, Mihara Memorial Hospital

5. Department of Neurosurgery, Obihiro Kosei Hospital

6. Department of Neurosurgery, Nakamura Memorial Hospital

7. Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine

8. Department of Neurology, Niigata City General Hospital

9. Department of Neurology, Iwate Prefectural Central Hospital

10. Department of Neurology, TOYOTA Memorial Hospital

11. Department of Neurosurgery, Tokushima University

12. Institute for Biomedical Sciences, Iwate Medical University

13. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University

14. Headquarters of the Medical Corporation ISEIKAI

Publisher

Japan Atherosclerosis Society

Subject

Biochemistry (medical),Cardiology and Cardiovascular Medicine,Internal Medicine

Reference19 articles.

1. 1) Thomalla G, Simonsen CZ, Boutitie F, Andersen G, Berthezene Y, Cheng B, Cheripelli B, Cho TH, Fazekas F, Fiehler J, Ford I, Galinovic I, Gellissen S, Golsari A, Gregori J, Gunther M, Guibernau J, Hausler KG, Hennerici M, Kemmling A, Marstrand J, Modrau B, Neeb L, Perez de la Ossa N, Puig J, Ringleb P, Roy P, Scheel E, Schonewille W, Serena J, Sunaert S, Villringer K, Wouters A, Thijs V, Ebinger M, Endres M, Fiebach JB, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Gerloff C and Investigators W-U: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset. N Engl J Med, 2018; 379: 611-622

2. 2) Koga M, Yamamoto H, Inoue M, Asakura K, Aoki J, Hamasaki T, Kanzawa T, Kondo R, Ohtaki M, Itabashi R, Kamiyama K, Iwama T, Nakase T, Yakushiji Y, Igarashi S, Nagakane Y, Takizawa S, Okada Y, Doijiri R, Tsujino A, Ito Y, Ohnishi H, Inoue T, Takagi Y, Hasegawa Y, Shiokawa Y, Sakai N, Osaki M, Uesaka Y, Yoshimura S, Urabe T, Ueda T, Ihara M, Kitazono T, Sasaki M, Oita A, Yoshimura S, Fukuda-Doi M, Miwa K, Kimura K, Minematsu K, Toyoda K and Investigators TT: Thrombolysis With Alteplase at 0.6 mg/kg for Stroke With Unknown Time of Onset: A Randomized Controlled Trial. Stroke, 2020; 51: 1530-1538

3. 3) Yaghi S, Willey JZ, Cucchiara B, Goldstein JN, Gonzales NR, Khatri P, Kim LJ, Mayer SA, Sheth KN, Schwamm LH, American Heart Association Stroke C, Council on C, Stroke N, Council on Clinical C, Council on Quality of C and Outcomes R: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke, 2017; 48: e343-e361

4. 4) Uyttenboogaart M, Koch MW, Koopman K, Vroomen PC, De Keyser J and Luijckx GJ: Safety of antiplatelet therapy prior to intravenous thrombolysis in acute ischemic stroke. Archives of neurology, 2008; 65: 607-611

5. 5) Nakamura A, Ago T, Kamouchi M, Hata J, Matsuo R, Kuroda J, Kuwashiro T, Sugimori H, Kitazono T and Fukuoka Stroke Registry I: Intensity of anticoagulation and clinical outcomes in acute cardioembolic stroke: the Fukuoka Stroke Registry. Stroke, 2013; 44: 3239-3242
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