Recent advances in the chemistry of pyridazine — an important representative of six-membered nitrogen heterocycles

Abstract

The review is devoted to recent advances in the chemistry of pyridazine — a six-membered heterocycle containing two nitrogen atoms in adjacent positions. The practical significance of title compounds is demonstrated and published data of the last decade devoted to them are considered systematically. The modern synthetic approaches to pyridazine derivatives are described in detail, analyzed and classified according to the precursor molecules involved in ring closure. The chemical properties of pyridazines are considered, including both reactions of the diazine ring and reactions of various substituents attached to the ring. Particular attention is given to the application of some pyridazine derivatives as pharmaceuticals, optical materials and ligands for catalysis. The bibliography includes 180 references.