THE GUT MICROBIOTA IS THE MISSING LINK IN THE PATHOGENESIS OF CELIAC DISEASE

Abstract

Results. During the analysis of the published pathogenesis of celiac disease (CD) is actively discussed. It is assumed that the change in gluten tolerance is formed under the influence of a number of different factors, including genetic predisposition and environmental factors. Much attention of researchers is paid to the study of disturbances in the composition of the intestinal microbiota and its functional activity in CD. Conclusion: It is discussed that the intestinal microbiota has gluten-degrading properties, which in turn may have a protective effect on the development of CD. The intestinal microbiota contributes to maintaining the integrity of the intestinal barrier, preventing the formation of a «leaky» intestine. On the contrary, a change in the composition of the microbiota can act as a significant link in the pathogenesis of gluten intolerance and exacerbate the course of the disease. The possibility of modulating the composition of the microbiota by prescribing probiotic preparations is being considered. The effectiveness of the use of probiotics containing Lactobacilli and Bifidobacterium bacteria in experimental and clinical studies as a preventive and therapeutic agent has been shown.