Identifying genomic variations in metabolic syndrome as a research strategy

Abstract

A review of modern Russian and foreign literature devoted to the genetic determinants of metabolic syndrome, mainly in young men, was carried out. When searching for information, the RSCI, Best Evidence, PubMed, Clinical Evidence, and Cochrane Library databases were used. It has been determined that the clinical manifestations of metabolic syndrome in young people are caused by complex intergenic interactions of polymorphisms of a number of genes (FTO, ACE, TCF7L2, ITGA2B, CSK, MTHFR). Among them, the CSK, FTO and TCF7L2 genes play a significant role. Timely identification of genetic predictors of metabolic disorders is of great clinical importance. The long-term consequences of risk factors such as excess body weight, insulin resistance and the resulting hypertension can accumulate exponentially. In this regard, it is necessary to conduct large cohort studies not to study the consequences of metabolic syndrome, but to identify the genetic factors in the formation of this syndrome for the possibility of targeted treatment for this category of people.