Implementation of pharmaceutical development using multivariate analysis of multi-criteria optimization on the example of the stage of purification of oligohexamethyleneguanidine hydrosuccinate-Reference-Cited by-同舟云学术

Implementation of pharmaceutical development using multivariate analysis of multi-criteria optimization on the example of the stage of purification of oligohexamethyleneguanidine hydrosuccinate

Published:2023-08-02 Issue:3 Volume:18 Page:265-279
ISSN:2686-7575
Container-title:Fine Chemical Technologies
language:
Short-container-title:Fine Chem. Technol.

Author:

Shatalov D. O.¹^ORCID,Trachuk K. N.¹^ORCID,Aydakova A. V.²^ORCID,Akhmedova D. A.¹^ORCID,Ivanov I. S.²^ORCID,Minenkov D. S.³^ORCID,Blazhevich I. Yu.⁴^ORCID,Kedik S. A.⁵^ORCID

Affiliation:

1. MIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies)

2. Institutе of Рhаrmасеutiсаl Тесhnоlоgiеs

3. Ishlinsky Institute for Problems of Mechanics, Russian Academy of Sciences

4. M.V. Lomonosov Moscow State University

5. MIREA – Russian Technological University (M.V. Lomonosov Institute of Fine Chemical Technologies); Institutе of Рhаrmасеutiсаl Тесhnоlоgiеs

Abstract

Objectives. The study set out to use mathematical modeling, in particular the method of multifactorial analysis of multicriteria optimization (MAMO), in the development of a pharmaceutical product.Methods. After carrying out experimental tests based on the proposed algorithmic sequence, the obtained data were interpreted using MAMO.Results. The possibility of using MAMO to solve the applied problem of purifying oligohexamethyleneguanidine hydrosuccinate (OHMG-HS), considered as a pharmaceutical precursor for the creation of medicines, was demonstrated.Conclusions. The expediency of using the proposed algorithm as a tool for pharmaceutical development is substantiated by identifying dependencies of the influence of purification conditions on the final content of admixtures in the target product.

Publisher

RTU MIREA

Subject

Inorganic Chemistry,Organic Chemistry,Fluid Flow and Transfer Processes,Process Chemistry and Technology

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