Affiliation:
1. State Educational Institution “Avicenna Tajik State Medical University”
Abstract
Aim. To study the effectiveness of bacteriophage therapy with the combined medicament “Complex pyobacteriophage” and “Sextafag”.Material and research methods. We examined 44 patients (24 women and 20 men) on an outpatient basis at the Department of Otorhinolaryngology of the Avicenna Tajik State Medical University.Results and its discussion. The results of the study of the microflora of the tonsils of patients with CT showed in 52% (13) of cases in 1st group of patients and in 56% (14) of cases in the second group presence of S. aureus, in 25%(6) and 28% (7) of cases mixed microflora - S. pyogenes together with S. salivarius was found and 25% (6) and 20% (5) cases showed S. aureus together with S. Pyogenes. It turned out that bacteriophage therapy with the “Complex pyobacteriophage” reduced a bit more the total contamination of the pharynx. However, there was no complete elimination of Staphylococcus aureus strains; single colonies remained in 5 (28%) patients with chronic tonsillitis.Conclusions. 1. The use of the medicament “complex pyobacteriophage” as a part of local therapy in patients with chronic tonsillitis is an effective and safe method of sanitation of the palatine tonsils.2. The specific selective antibacterial action of this drug prevents a prolonged stay of the focus of infection, thereby prolonging the period of remission.3. Prevention of the focus of infection in the tonsils contributes to the increase of local and general immunity of the body.
Reference9 articles.
1. Ayzenshtadt A.A. Ispolzovanie bakteriofagov v terapii zabolevaniy LOR-organov u detey [Use of bacteriophages in the treatment of ENT diseases in children]. Voprosy prakticheskoy pediatrii - Questions of practical pediatrics, 2018, Vol. 13, No. 2, pp. 47-51.
2. Pavlova G.V. Vtorichnaya profilaktika obostreniy khronicheskogo tonzillita bakteriofagalnymi sredstvami [Secondary prevention of exacerbations of chronic tonsillitis with bacteriophageal agents]. Vestnik otorinolaringologii - Bulletin of otorhinolaryngology, 2019, No. 2, pp. 46-49.
3. Kapranskaya G.R. Khronicheskiy tonzillit: raznye vzglyady na staruyu problem [Chronic tonsillitis: different views on an old problem]. Meditsinskiy Sovet – Medical Council, 2013, No. 5-6, pp. 69-71.
4. Karpova E.P. Vozmozhnosti profilaktiki lecheniya limfadenotonzillyarnoy patologii [Preventive treatment options for lymphadenotonsillar pathology]. Rossiyskiy meditsinskiy zhurnal - Russian medical journal, 2014, No. 25, pp. 1842-1845.
5. Kolesnikova O.M. Mikrobnyy peyzazh nebnykh mindalin pri obostrenii khronicheskogo tonzillita [Microbial landscape of the palatine tonsils during exacerbation of chronic tonsillitis]. Vrach - Doctor, 2017, No. 11, pp. 49-51.